Simvastatin Combined with Ezetimibe in the Treatment of Patients with Hypercholesterolemia
Mi Liu · Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease · 2010
Objective To investigate the therapeutic effectiveness and safly of simvastatin combined with ezetimibe on patients with hy-percholesteremia.Methods 71 patients with hypercholesterolemia were divided into the simvatatin group and combination group(simvastatin combined with ezetimibe).which were treated with correspond methods.The therapy lasted for twelve weeks in both two groups.The levels of TC,TG,HDL-C,LDL-C were measured in pre-treatment and post-treatmen.Results After twelve weeks treatment with simvastatin,the lipids of TC、LDL-C、TG were decreased and HDL-C ele-vated remarkably than those at baseline,and with P0.05.When combined with ezetimibe for twelve weeks,the lipid level of TC、LDL-C、TG was reduced than that of merely using simvastatin,and with P0.01 in respect.The side effects rates had no difference between two groups statistically(P0.05).Conclusion The effect of combination of ezetimibe and simvastatin is better than that simvastatin alone,in regulating cholesterol metabolism,and comb-nation of ezetimibe and simvastatin is safe.