The Effect on Essential Hypertension Left Ventricular Hypertrophy With Combined Usage of Felodipine and Fluvastatin
Guo Chang-jian · China Practical Medicine · 2011
Objective to estimate the effect on Essential hypertension left ventricular hypertrophy with combined usage of Felodipine and Fluvastatin Methods 80 patients with Essential hypertension left ventricular hypertrophy were randomly divided into A, B groups,For 6 months,A group of drug taking Felodipine,5 mg per day;B group of drug taking Felodipine 5 mg and Fluvastatin 40 mg per day. Before and after treatment with serum was measured PCⅢ、NO content by radioimmunoassay,Assessment ventricular hypertrophy with echocardiography before and after treatment respectively.Results Two groups of patients blood pressure lowering drug therapy, hile LVM I and PCⅢ in serum concentrations were lower than those before treatment(P0.01),B groups decreased serum concentration PCⅢ was more obvious than the A group(P0.05),LVM I reduction in the two groups were significantly different(P0.05),NO content in B group changes after treatment was significantly higher than group A(P0.05)。Conclusion combined usage of Felodipine and Fluvastatin on Essential hypertension left ventricular hypertrophy and diastolic function for improving the synergy has significant effect than single agent