Preliminary study of establishment of acute pulmonary thromboembolism in dogs
Deng Wei-w · Journal of Diagnostics Concepts & Practice · 2007
Objective To establish dog acute pulmonary thromboembolism(PTE) models and to evaluate the changes of pulmonary arterial pressure(PAP) and pathology of the models.Methods Eight dogs were randomly divided into a normal group in sham operation and a model group in injection of autologous blood clots.Results PAP of the model group was remarkably higher than that of the normal group at all 4 time points after model establishment.The difference showed statistical significance.The histopathologic and morphologic difference between the two groups was also significant.Not only could thrombosis in pulmonary vasculars be observed,but inflammatory reaction was observed also in the model group.Conclusions Acute PTE model in dogs successively established by means of injecting autologous blood clots provides a model basis for more studies of mechanism and therapies.