Chemosensitivity of Eight Anti-cancer Drugs on Breast Cancer Cells
Weihong Yu, Cai-feng Yue, Meng Fanjuan · Carcinogenesis,Teratogenesis and Mutagenesis · 2005
BACKGROUND AIM: To investigate the chemosensitivity of eight anti-cancer drugs in breast cancer cells of different individual. MATERIAL AND METHODS: The breast cancer cells from 41 patients were being exposed to eight anti-cancer drugs for 48 h, at concentration according to 1 plasma peak concentration (1 PPC) . The inhibition rate of tumor cells was used in vitro MTT assay to determine chemosensitivity. RESULTS: At amount of 1 ×105 tumor cells/ perwell in the present of 1 PPC, the breast cancer cells had higher chemosensitivity to the EADM, MTZ treatment with the inhibition rate of (44.30±10.66) %, (44.14 ±13.05) % than other of drugs, and but they were of no significant. A statistically significant difference was P 0.01,P 0.05 and P0.05 in chemosensitivity of eight drugs between clinical stages, pathology types and lymphoid metastasis. CONCLUSION: Eight anti-cancer drugs had a difference chemosensitivity to the breast cancer cells from 41 patients. The In vitro MTT assay was essential for predicting chemosensitivity of individual breast cancer patients.