Recent advances in research on survivin and its moecular antagonists
Wei-Lin Huang, Xiangjun Zhou, Yong‐Xiang Wang · Zhongguo yaolixue tongbao · 2005
Survivin is a member of the IAP family, which has been shown to localize to various components of the mitotic apparatus. Survivin is not only an apoptosis inhibitor, but a mitotic regulator as well. Survivin is Absolutely undetectable in normal tissues, but over-expressed in all the most common human cancers. Survivin is considered as an important target in cancer treatment, and the research on its molecular antagonists has gained encouraging achievements.