Association of Polymorphisms of Angiotensin-Converting Enzyme 2 Gene With Antihypertensive Effects of Captopril in Women
Haiying Wu · Zhongguo xunhuan zazhi · 2008
Objective:Some polymorphisms in genes of renin-angiotensin system are associated with the blood pressure response to antihypertensive drugs.This study investigated the association of polymorphisms of ACE2 and ACE with blood pressure response to antihypertensive medications.Methods:A total of 3,408 untreated hypertensive patients were randomized to Captopril,Atenolol,Hydrochlorothiazide,or Nifedipine sustained release treatments for 4 weeks to determine the association of blood pressure response with polymorphisms of ACE2.Two single nucleotide polymorphisms of ACE2 and ACE I/D were genotyped by standard PCR restriction fragment length polymorphism analysis,and subsequently confirmed by randomly selected bidirectional sequencing.Results:Female hypertensive carriers of ACE2 rs2106809 T allele had 3.3 mmHg lower reduction in diastolic blood pressure response to captopril than did CC genotype female carriers after adjusting for pretreatment blood pressure,age,body mass index,and ACE I/D polymorphism(P=0.019),but this association was not found in men and in other antihypertensive drug treatment groups.No association was found between ACE DD genotype and blood pressure response to any antihypertensive drugs.The difference between CC and CT+TT genotype groups was larger in captopril group than in group aggregated other drugs in women.Conclusion:ACE2 T allele can affect blood pressure responses to ACE inhibitors in women.