Ultrasonographic and serum biochemical studies on liver damage of workers exposed to mixed benzene in low concentration
Ning Fe · Zhiye yu jiankang · 2015
[Objective]To study the ultrasonographic and serum biochemical changes of liver damage of workers exposed to mixed benzene in low concentration,investigate the clinical significance.[Methods]110 workers(80 men and 30 women)exposed to low concentration mixed benzene(benzene,toluene and xylene) were enrolled in the exposure group. According to the similar constitution of age,length of service,and gender,110 healthy persons who have not exposed to mixed benzene were recruited in the control group. By the color Doppler ultrasonography,the exposure group and the control group received the routine liver ultrasound examination,middle hepatic vein diameter and frequency spectrum. And the serum liver biochemical indexes were detected. [Results]The detection rate of hepatomegaly,fatty liver,liver abnormal echo and abnormal results in hepatic vein spectrum in the exposure group was respectively 10.90%,16.36%,33.63% and 19.09%,which was higher than that in the control group(2.72%,7.27%,12.72% and 8.18%),and the differences were statistically significant(all P0.05). The serum biochemical examination showed that the detection rate of increased activity of AST and ALT in the exposure group was respectively 15.45% and 12.72%,which was higher than that in the control group(5.45% and 3.63%),and the differences were statistically significant(both P0.05).[Conclusion]The mixed benzene exposure injures not only blood system as but also liver.The workers exposed to mixed benzene in low concentration show significant damages in liver sonographic examination,middle hepatic vein spectrum and serum biochemical indexes as compared with the control group. The early ultrasound examination can discover the morphologic and hemodynamic changes of liver, and the serum biochemical tests can determine the hepatic functional change. The combination of two ways contributes to the early judgment of the liver damage,provides the basis and methods for early detection of liver damage and protection of health,which has the clinical significance.