Synthesis and anti-HIV activity of a novel water-soluble C_(60)-dehydroabietylamine pyrrolidine derivative
Zhongxiang Lin · Nanjing Linye Daxue xuebao · 2013
A novel water-soluble dehydroabietylamine fullerenol was synthesized and its anti-HIV activity had been evaluated.It was prepared by the hydroxylation of fulleropyrrolidine which was synthesized through the 1,3-dipolar cycloaddition of C60,sarcosine and glyoxal dehydroabietylamine single Schiff base.The structures of all the compounds were characterized by IR,ESI-MS,MALDI-TOF-MS,1H NMR,13C NMR,elemental analysis and TGA.The bioassay results showed that the synthesized dehydroabietylamine fullerend had great anti-HIV activity against HIV-1 reverse transcriptase in vitro and IC50 was 47.89 μg/mL.