Effects of varied dosage atorvastatin on inflammatorv factors and prognosis in aged patients with coronary heart disease and atrial fibrillation
Tao Gui-zhou · Journal of Clinical Cardiology · 2010
Objective:To observe the effects of different dosages of atorvastatin on serum inflammatory factors and prognosis in patients with coronary heart disease (CHD) and atrial fibrillation (Af),and to investigate its possible mechanism of anti-atrial fibrillation.Method:One hundred aged patients with CHD and atrial fibrillation were randomly divided into two groups:10 mg atorvastatin group (n=50) and 20 mg atorvastatin group (n=50).Changes of levels of serum inflammatory factors (high sensitive C-reactive protein,tumor necrosis factor-alpha,interleukin-6),left atrium diameter (LAD) and atrial natriuretic peptide (ANP) in two groups were observed before and after treatment.Maintenance rate of sinus rhythm and incidence rate of embolism were also recorded at the 6th month after treatment.Result:The serum levels of hs-CRP,IL-6,TNF-α were significantly decreased in 6 months after treatment in both groups compared to those before treatment (P0.05),especially in the 20 mg atorvastatin group (P0.05).LAD and ANP in 20 mg atorvastatin group were significantly smaller than those in 10 mg atorvastatin group (P0.05);Maintenance rate of sinus rhythm was significantly higher and incidence rate of embolism was obviously lower in 20 mg atorvastatin group than that in 10mg atorvastatin group at the 6th month (P0.05).Conclusion:Atorvastatin could reduce levels of serum inflammatory factors,LAD,ANP and incidence rate of embolism and increase the maintenance rate of sinus rhythm in aged patients with CHD and Af.Those effects were dose dependent.The inhibitory effect of atorvastatin on serum inflammatory factors may be one of its anti-Af mechanisms.