Effects of esomeprazole on pharmacokinetics of atorvastatin in dogs
Yang Fu · Chinese Journal of Hospital Pharmacy · 2013
OBJECTIVE To study the effects of esomeprazole on pharmacokinetics of atorvastatin in dogs.METHODS Eight Beagle dogs were randomly divided into two groups with dicycle and double cross test.One group was administrated with atorvastatin(5 mg·kg-1) for 6 days,and the other group was administrated with atorvastatin plus esomeprazole for 6 days.Plasma concentrations of atorvastatin in blood were measured by HPLC.The main pharmacokinetic parameters were calculated and compared by statistical analysis.RESULTS The pharmacokinetic parameters(AUC(0-t)) had statistical difference between two groups(P0.05);The other pharmacokinetic parameters had no significant changes(P0.05).CONCLUSION Esomeprazole could apparently increase the bioavilibility of atorvastatin,while they almost had no effect on drug elimination process.