The research progress in artemisinin and its derivatives
Guo Chun · Zhongguo yaowu huaxue zazhi · 2012
The artemisinin and its derivatives as new antimalarial drugs have been used successfully in the treatment of multidrug-resistant Plasmodium falciparum strains.At the same time,these compounds also having anti-tumor,anti-fugal,anti-arrhythmic,anti-parasitic and other activities,have aroused widespread concern.With wide use of artemisinin and its derivatives in clinic as antimalarial drugs,the drug resistance has emerged,which bring new challenge for malarial treatment.The scholars all over the world carry out a lot of research on artemisinin derivatives with better activities in vitro in order to find safer,more efficient and economical antimalarial drugs.In addition,other application of artemisinin and its derivatives has also made considerable progress with the deep research on artemisinin.Because molecular biology,drug activity screening method,pharmacy information and other related scientific disciplines being developed and applied,and new synthetic methods being applied and improved,it is believed that a new generation of artemisinin-based drugs has wider application.In this paper,the structural modification of artemisinin derivatives and their activity are reviewed.