The Application of the Bioisosterism in the New Drug Research
Shuyue Wang · 2003
The paper discusses that to discover the rule of bioisosterism is helpful for the new drug research. Through indexing document retrieval.it explains the definition of bioisosterism.the character.the application range of the classic esample of several type bioisosterism,and indicates that there are some atoms or groups that ex-change with each other ,which have the equal outer electron number.or have similarities in some important parame-ters.such as volume,shape,O/Wdistribution rate.chemistry reaction(include metabolism similarity). We can get the new compound through structure modification, which is better or similar or anti the effect of pro-drugs. So.It is a lower difficult and risk.higher successful way,and play an important role in the new drug research, especially its adaptablity for our recent conditions in drug industry.