Principles of Pro-drugs and Drug Design
Wang Shu · 2003
The Paper xplores the law of prodrug principles in the new drug design to promote the development of the drug research.Through indexing the document,we can synthesis and analyze the standard examples of prodrug principles in the new drug design.Prodrug principles are widely used in the new drug design.It can be applied to modifying certain drug structures which contain such groups as Carbonyl,Hydroxy and Amino to synthesize new drugs.And it also can serve for Azotype,Manniss base type,Nitrogen monoxide type prodrug,and some new structure prodrug such as opencircletype,closecircletype and so on.The way of designing new drugs through the prodrug principles is worth spreading and is adaptable to our country conditions.And it is less risk,needs investment,and has higher success rate.Through this way,we can both keep or enhance the drug effects and overcome some sideeffects of the drugs.