Analysis of angiotensin converting enzyme gene polymorphism in myocardial infarction
Xi Chen · Journal of Taishan Medical College · 2000
Objective: To research inte the relationship between deletion polymorphism in angiotensin converting enzyme (ACE) and myocardial infarction Methods: A 287 bpI/D polymorphism in intron 16 of the ACE gene was examined by polymerase chain reaction in a cross sectional study of 41 subjects and 58 patients with myocardial infarction. Results: The frequencies of DD genotype were 41 4% and 22 0%, ID genotype, 31 0% and 41 5%, II genotype, 27 6% and 36 6% in myocardial infaction and normal human respectively. The frequency of DD genotype in patients was higher than that in the control group, χ 2=4 21,P0 05. There is no significant difference of DD genotype between male and female. Conclusion: It suggests that the DD genotype of ACE might be an important potent risk factor for myocardial infarction.