Influence of angiotensin-converting enzyme polymorphism on the responses to metoprolol in hypertensive patients
Yishi Li · The Chinese Journal of Clinical Pharmacology · 2010
Objective To study the influence of angiotensin-converting enzyme(ACE)gene insertion/deletion(I/D)polymorphism on the responses to metoprolol in hypertensive patients.Methods Patients received metoprolol(100 mg once daily)as monotherapy for 8 weeks.Before and after treatment,24-hour ambulatory blood pressure monitoring(ABPM)and dynamic electrocardiogram(DCG)were performed.Genotyping analysis was conducted by PCR RFLP assay.Results After 8-week treatment,significant difference was detected in 24-hour average heart rate[(67.6±6.6)beats min-1 in II group vs(70.9±7.3)beats·min-1 in D+ group,P=0.045].The difference during the treatment was(8.73±8.16)beats·min-1 in II group vs(5.46±6.28)beats·min-1 in D+group(P=0.046).Conclusion The ACE gene I/D genotype affected metoprolol-induced reduction in 24-hour average heart rate.