Comparison of indapamide or hydrochlorothiazide respectively with losartan in combination therapy on patients with essential hypertension and left ventricular hypertrophy
Zhaoqian Liu · Linchuang huicui · 2003
Objective To compare the efficacy of long term treatment with indapamide/losartan and low dose hydrochlorothiazide/losartan on blood pressure,left ventricular hypertrophy (LVH) and LV diastolic function in hypertensive patients with LVH.Methods Eighty six hypertensive patients with LVH were randomly divided into two groups.The first group received indapamide 1.25 2.5 mg/d and losartan 50 100 mg/d for 48 weeks.The second group received hydrochlorothiazide 12.5 25 mg/d and losartan 50 100 mg/d for 48 weeks.Results Blood pressure was significantly reduced in both groups (P 0.05 ).The total effective rates were 92.9% in the first group and 90.0% in the second group (P 0.05 ).The LVH and left ventricular diastolic functions in both groups were improved significantly (P 0.01 ).But in the indapamide combination losartan group above targets of LVH and left ventricular diastolic function changes were more remarkable than those in the hydrochlorothiazide combination losartan group (P 0.01 ).Adverse reaction was mild in both groups,indapamide/losartan was superior to hydrochlorothiazide/losartan in reducing blood glucose and triglycerides profile.Conclusion Indapamide with losartan is more effective with less adverse reactions than hydrochlorothiazide with losartan in treating moderate to severe hypertesive patients with LVH, which may be an appropriate choice of long term antihypertensive therapy.