Prediction Signaling Transduction Pathways of Cancer related Apoptosis Protein Par-4
Yanchao Zhao, Shubo Zhang, Chan Danile Waitin, Miao He · Acta Scientiarum Naturalium Universitatis Sunyatseni · 2010
Based on the Support Vector Machine algorithm,the protein-protein interactions(PPI) networks between Par-4,the cancer-related apoptosis protein,and related proteins have been built.There are 82 proteins have been predicted interacting with Par-4.The proteins are classified into eight groups by biological functions,which include protein kinase,death receptor associate factor,ubiquitin-protein ligase,special disease associate proteins,DNA replication related proteins,special structure associate protein,regulatory protein and others.Combined with literatures mining and molecular chaperones of Par-4 searching from BOND database,two new signal transduction pathways of Par-4 have been deduced.In this paper,we first discover that Par-4 interacts with a group of ubiquitin-proteins.We find that Par-4 has complicated interactions with many proteins.Par-4 plays a major role in some apoptosis pathways.