Electrocatalytic oxidation of simvastatin at SDBS self-assembled monolayers and RGO modified carbon paste electrode and its electrochemical determination
Ru Zhang · Chemical Research and Application · 2013
Electrocatalytic oxidation and electrochemical kinetics of simvastatin(SMV) were investigated at sodium dodecyl benzenesulfonate(SDBS) self-assembled monolayers and graphene(RGO) modified carbon paste electrode(SDBS-RGO / CPE).The experimental results showed that SDBS-RGO / CPE showed an excellent electrocatalytic activity towards SMV electrochemical oxidation.The electrochemical kinetic parameters were also determined by cyclic voltammetry(CV) and chronoamperometry(CA).The oxidation peak current of catalytic oxidation of SMV versus its concentration had a good linear relationship in the concentration range of 6.0 × 10-5mol·L-1~ 4.5 × 10-4mol·L-1and the detection limit of 5.0 × 10-6mol·L-1(S/N=3) by square wave voltammetry(SWV).At the same time the supposed method have been applied in the electrochemical quantitative determination of SMV content in commercial tablet samples and the determination results meet the requirement of the quantitative determination.