Research advances in compound antihypertensive agents based on CCB/ARB
Zhang Guang-ling · Zhongguo xin yao zazhi · 2013
Hypertension is a well established risk factor for cardiovascular diseases,which may result in dysfunction of organs such as heart and kidney.The optimal combination of antihypertensive agents will provide a more superior antihypertensive effect than either agent administered as monotherapy,and have different but complementary mechanisms of action as well as a favorable safety and tolerability profile.In recent years,great progresses had been achieved in the worldwide research development(RD) and clinical application of compound antihypertensive agents.The RD,mechanisms of action,pharmacodynamics and pharmacokinetics,clinical studies of compound antihypertensive agents based on CCB/ARB were reviewed in this article.These compound agents include amlodipine besylate and telmisartan,amlodipine besylate and valsartan,amlodipine besylate and olmesartan medoxomil,amlodipine besilate and candesartan cilexetil,amlodipine besylate and hydrochlorothiazide/valsartan,and amlodipine besylate/hydrochlorothiazide/olmesartan medoxomil.