Correlation between Apolipoprotein CI gene polymorphisms and lipid-lowering efficacy of atorvastatin
Zhengwei Xu · Zhongguo linchuang yaolixue yu zhiliaoxue · 2010
AIM:To investigate the effect of polymorphisms in ApoCⅠ gene on the treatment efficacy of small dose of atorvastatin on hyperlipidemia.METHODS:94 cases in 387 patients with hyperlipidemia were treated with oral administration of atorvastatin 10 mg/d.The TC,TG,LDL-C,apoA1 and apoB were measured before treatment and after 4,8,12 weeks of treatment.The polymorphisms of ApoCⅠgene on HpaⅠlocus were determined by using PCR-RFLP method.RESULTS:In 387 patients,the relative frequency of H2 allele and H1 allele were 0.3165 and 0.6835,respectively.After 8 weeks of treatment,the decreasing in level of LDL-C was more prominent in non H2 carriers than that in H2 carriers(P0.05),but this difference was not found in TC,TG and ApoB.CONCLUSION:The efficacy of lipid-lowering therapy was no difference in Apo CⅠ gene polymorphisms.