PHARMACODYNAMIC ANALYSIS OF ANTIARRHYTHMIC AGENT GALLANILIDE (603)
Li D · Journal of Shanghai Medica · 1984
Gallanilide [N-(β-diethylaminoethyl)-N-(O-methylphenyl)-3', 4', 5'-trime-thyloxycarboxylamide maleate (603)] is a new synthetic compound with antiarrhy-thmio action. The change of electrically induced ventricular fibrillation threshold (EIVFT) is chosen as a graded quantitative pharmacological response in anesthetized rabbits for the study of pharmacodynamics of 603. The observed pharmacological data are converted, via the use of a dose-effect curve, to values corresponding to the relative drug levels at the site of action. From kinetics of reversible pharmacological effect, we used Hill equation. It was found that the equation could determine the time course of an observed pharmacological effect (E). This equation can be written as:where E stands for the change EIVFT at the concentration (or dose) C, Emax is the maximum intensity of the pharmacological response when c-. Other calculated parameter values are as follows: fall rate of pharmacological effect R=0.1089min-1, drug elimination rate constant K =0.06498min-1, biological half life t1/2=12.6min.