The Study on Unfolding Features of Denaturant-induced Multiple-domain Proteins
Liaofu Luo · Acta Scientiarum Naturalium Universitatis Neimongol · 2003
The unfolding features of the multiple-domain proteins are analyzed in terms of sequential model.The formulae that can describe the protein unfolding processes of the multiple-domain proteins are deduced by means of adsorption kinetics.The unfolding processes of the typical two-domain proteins are discussed in details. Under certain conditions,the explanation far the double sigmoidal curves of two-domain proteins is given.At the same time, some expectations for several different unfolding processes are made.