THE PROSPECT, PROMISES AND HINDRANCES OF STATIN BASE MOLECULES: LOOK BACK TO LOOK FORWARD
Meor Mohd Affandi MMR, Minaketan Tripathy, Abu Bakar Abdul Majeed · International Journal of Pharmacy and Pharmaceutical Sciences · 2016
This review narrates the importance of the statin-based molecules and their inherent challenges during their administration. The chronological appearance of the statin, their source and the journey with time so to evolve as one of the successful cholesterol-lowering agents to prevent the morbidity and mortality especially related to coronary heart disease have been illustrated along with their recent utilities in neurodegenerative diseases. The statins, because of their respective physicochemical characters pose several challenges in regards to their effective administration to the patients. One of the major issues related their poor bioavailability is their aqueous solubility. The different approaches for the enhancement of solubility and hence bioavailability have been discussed systematically. This review finally suggests the importance of more related research in regards to their successful administration so to have greater realization of therapeutics efficiency. Keywords: Statin-based molecules, Poor solubility, Solubility enhancement