The Learning and Evolution of Medicinal Chemistry against Kinase Targets
Martin E. Swarbrick · Royal Society of Chemistry eBooks · 2011
More than 500 kinases have been identified in the human genome and, given the importance of phosphoryl transfer processes in cellular signal transduction pathways, it is no surprise that the kinome has been extensively investigated as a family of potential drug targets.1,2 A large number of small mo...