Chapter 11. Future Targets and Chemistry and ADME Needs
Dennis A. Smith, David S. Millan · RSC drug discovery/RSC drug discovery series · 2010
This chapetr examines drug targets within the human genome and looks at the likely future targets small molecule drug discovery will try top exploit. The chapter suggests that it is unlikely that small molecule drug targets will come from new gene families. The largest gap appears in the ability to translate some of the famileis into drugs with good or reasonable pharmacokinetics. There is a gap in understanding drug disposition, particularly as compounds move to higher lipophilicities and polar surface areas. Also discussed are the new chemical processes that are required to exploit these targets.