Mammographic Density and Breast Cancer in BRCA1/BRCA2 Carriers.
Marina Pollán, Teresa Ramón y Cajal, Isabel Chirivella, Juan José Izquierdo Miranda, Àlex Teulé, Joan Brunet, Ana Beatriz Sánchez‐Heras, Gemma Llort, Judith Balmañà, Viviana Aguirre Carvajal, Elena Hernández-Agudo, M. J. Juan-Fita, I. Tena-García, Luis Robles, C. Guillén, Pedro Pérez‐Segura, Mari Sol Luque-Molina, Susana Pablo Hernando · International Journal of Epidemiology · 2015
INTRODUCTION: Mammographic density (MD) is one of the strongest determinants of breast cancer (BC). In this study, we compared MD in BRCA1/2 carriers and non-carriers from BRCA1/2 families and investigate the association between MD and BC among BRCA1/2 carriers per type of mutation and tumor subtype. METHODS: The study was carried out in female members of BRCA1 and BRCA2 mutation-positive families seen in 16 Spanish Genetic Counseling Units. A total of 1039 women signed the informed consent and answered the questionnaire. Mammograms from 353 BRCA1-carriers, 360-BRCA2 carriers and 247 non-carriers were available and read by a single radiologist using a 5-category scale of MD ( 75%). MD distribution in carriers and non-carriers was compared using ordinal logistic models, adjusted for age, BMI, menopause, parity, type of image and subsequent BC development. The association between MD and BC in BRCA1/2 carriers was studied using logistic regression models, adjusted for age, BMI, menopausal status, parity, type of image, time elapsed from mammogram to BC diagnosis (cases) or end of follow-up (non cases). Huber-White robust estimators of variance were used to take into account correlations between family members. A similar multinomial model was used to explore this association by BC subtype.