Modeling of cytotoxicity on some non- nucleoside reverse transcriptase inhibitors of HIV-1: role of physicochemical parameters
Brij Kishore Tiwari, Mamta Thakur, Mamta Thakur, N.D. Pandey, Shahid S. Narvi, P Sudele · ARKIVOC · 2006
In present study efforts have been made to develop a mathematical model for a set of 18 1-[(2hydroxyethoxy)-methyl]-6-(phenylthio)thymine (HEPT) Derivatives.The biological activity modeled in present investigation is cytotoxic concentration (log 1/C).To investigate the cytotoxic behavior of HEPT derivatives, classical and non-conventional physicochemical properties are tested separately.On the basis of the results obtained we model the compound having maximum predictive potential.