Male-specific metabolism of simvastatin by rat liver microsomes.
Naotaka Uchiyama, Yayoi KAGAMI, Yuko SAITOH, Masakatsu Ohtawa · Chemical and Pharmaceutical Bulletin · 1991
Simvastatin was more effectively metabolized by the liver microsomes of male rats than females. The sex difference appeared in the composition of the metabolites. Two male-specific metabolites were identified by NMR and mass spectrometry as 3''-hydroxy and 3',3''-dihydroxy-delta 4',5' derivatives of simvastatin.