Mutual Relation Ship between ED50 and a New Method for Comparing Antibacterial Activity.
Toshiharu Fujiura, Yutaka Kawazoe · Japanese Journal of Hospital Pharmacy · 1994
The Mutual relation ship was investigated between ED50 and a reliable method which was previously reported, i. e., the area under the effect vs. time curve (AUE). In comparing AUE, AUC and MIC, AUE was found to be the most closely related with ED50. AUE involves are conversion of time-concentration curves into time-effect curves, and is considered to be a simple and reliable method for definitely demonstrating antibacterial effects.