Augmented reality supporting innovation and accuracy in advanced radiation therapy facilities
S. Spoto, F. Bourhaleb, G. Petrone · Radiotherapy and Oncology · 2016
ICTR-PHE 2016 S97 Material and Method: This work was carried out with MCNP and Geant4 codes.The 10x10x10 cm3 cubic water phantom and a tumor region with a size of 1x1x1 cm3 were simulated.Factors such as different concentrations and GNP sizes were implemented into the simulation, so as to obtain the optimum results, specifying the maximum absorbed dose within the tumor while sparing healthy tissue.In a certain concentration, different sizes of GNPs including 30, 50, 70 and 100 nm were defined within the tumor and the absorbed dose by the GNPs-loaded tumor were calculated for different sizes.Similarly, the absorbed dose was calculated for different concentrations of 7, 10, 18 and 30 (mg Au/ gram of tumor) in a certain size of GNPs.The dose enhancement factor which is defined as the ratio of the absorbed dose by the tumor in the presence of nanoparticles to the absorbed dose by the same organ in the absence of nanoparticles was estimated for different concentrations and sizes of GNPs.Results and Conclusion: The calculations show results for different sizes and concentrations and a comparison is made between the two Monte Carlo codes (MCNP and Geant4).In a certain diameter of GNPs the higher concentration made more increase in absorbed does by the tumor.In a certain concentration, higher size of GNPs made higher absorbed dose by the tumor.Given the fact that therapeutic applications of GNPs in acquiring the proper DEF have demanded much attention in recent years, defining the proper size and concentration would be considered extremely vital for pre-treatment plans.