A Simplified Process for the Manufacture of AZD0530, a Potent SRC Kinase Inhibitor
Steven A. Raw, Brian A. Taylor, Simone Tomasi · Organic Process Research & Development · 2011
An efficient process for the manufacture of AZD0530 1, a potent SRC kinase inhibitor, has been developed. The key transformation, reaction of monofluoroanilide 7 with alcohol 8, was much simplified between manufacturing campaigns. The development of a robust, efficient, and scalable process for this transformation drew on both a practical and theoretical understanding of the process and is described herein