Adsorption of Insulin to Infusion Containers and Infusion Sets and Its Prevention.
Tsuneaki Yamanouchi, Shuka Aono, 泰彦 三村, Isao Adachi, 美鈴 角田, Tomoko Nagasawa, Mika Morita, Saiko Yano, Shirou Hayashi, Yoshio Daimon · Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) · 2001
We studied the effect of total-vitamin addition, insulin concentration and the exchange of infusion containers on the adsorption of insulin to infusion containers and infusion sets (line and filter). The adsorption of insulin to infusion containers and infusion sets decreased by the addition of total-vitamin injection, and the addition of a half-volume of total-vitamin injection also gave a similar result.In the absence of total-vitamin injection, adsorption to the infusion containers was not influenced by the concentrations of insulin (5-40 units). However, the adsorption to infusion sets decreased as the concentration of insulin increased. In the presence of total-vitamin injection, adsorption to infusion containers and infusion sets decreased by the same degree, but was not influenced by the change in concentrations of insulin (5-40units).When the infusion container without total-vitamin injection was changed to a new one with total-vitamin injection, a rapid increase in the insulin outflow of the infusion set was observed. The increase in the insulin outflow could be prevented by the addition of a half-volume of total-vitamin injection into both infusion containers. These results suggest that the constant addition of a half-volume of total-vitamin injection containing surfactants into each infusion container is an effective way to slightly change the insulin outflow of infusion set when two containers a day are needed.