Database of Cytochrome P450 Activities and Drugs on Personal Computer.
TOSHIO NISHIYAMA, Shin Iguchi, Chisae Y. Umezawa · Japanese Journal of Hospital Pharmacy · 1998
Cytochromes P450 (P450) are known to be the enzymes responsible for the metabolism of most drugs. P450 data are thus important for the drugs clinical use since they are useful for predicting drug interactions and adverse side effects. From this point of view, we constructed a database including data obtained by in vitro methods using cDNA-expressed P450 and liver microsomes as well as data obtained by in vivo methods. the principal stored in vitro data are P450 forms, substrates and effects of inhibitors. The in vivo method data are administration methods, plasma concentrations of drugs, and DSST (digit symbol substitution test).The data employed in this database were collected from the literatures, and the system was constructed using Access, Excel and Visual Basic 4.0 of Windows'95.