Pharmacokinetic of simvastatin study in Malaysian subjects
Khaled Mohammed Alakhali · IOSR Journal of Pharmacy (IOSRPHR) · 2013
The pharmacokinetic of simvastatin 40 mg tablet was assessed in 9 healthy Malaysian male subjects after a single oral dose in Pinang Hospital, Malaysian.Blood samples were collected at specified time intervals, plasma separated and analyzed for simvastatin using validated LC-MS-MS method at unversiti sains Malaysia.The pharmacokinetic parameters AUC 0-24 C max , T max , t 1/2 , K e , Cl and V d were determined from plasma concentration-time profile for simvastatin.The results of this current method were consistent with other methods previously reported.