The Impact of Lipophilicity in Drug Research: A Case Report on ß-Blockers
Raimund Mannhold · Mini-Reviews in Medicinal Chemistry · 2005
The key importance of lipophilicity in bio-studies is discussed for ß-blockers. Examples of their lipophilicity-dependent pharmacological properties including pharmacokinetic, pharmacodynamic and clinical aspects are reviewed. Comprehensive lipophilicity compilations of ß-blockers are lacking so far. LogP calculations with 10 programs for 30 clinically relevant ß-blockers are presented for the first time in this review. Keywords: blockers, pharmacokinetic, pharmacodynamic and clinical properties, lipophilicity, logp calculation programs, logp compilation for ß-blockers