A Unified Theory for Quantal Responses to Mixtures of Drugs: Competitive Action
P. S. Hewlett, Robin L. Plackett · Biometrics · 1964
Models for quantal responses to drugs acting competitively are considered. The models are derived by taking the model for graded responses developed largely by Gaddum and applying the principle that a quantal response occurs when an underlying graded response reaches a critical level of intensity. Dynamic equilibria, between the drugs and receptors in the tissues of the units of biological material, are assumed. Three cases occur: