Diffuse scattering from stacking faults: scaling of pair correlation function
Dhananjai Pandey, P. Tiwary · Acta Crystallographica Section A Foundations of Crystallography · 2011
The structure reveals that the nanobody binds a hydrophobic helix through its CDR1 and CDR3 loops, abolishing a well characterized interaction between the capsid N-and C-terminal domains.Interestingly, the interaction forms a hydrogen bond network with capsid residue N73, which is associated with host antiviral restriction.Structural alignments of this complex with high resolution crystal structures of pentameric and hexameric capsid building blocks suggests that upon binding, the nanobody sterically prevents the incorporation of either pentamers or hexamer to the mature capsid lattice.