Use of PI Index in Computer-Aided Designing of Bioactive Compounds
Padmakar V. Khadikar, Mircea Vasile Diudea, Jyoti Singh, Peter E. John, Anjalee Shrivastva, Shalini Thakur Singh, Sneha Karmarkar, Meenakshi Lakhwani, Purnima Thakur · Current Bioactive Compounds · 2006
In this review we critically examine PI (Padmakar-Ivan) index of organic compounds acting as drugs and discussed its applications in Computer-Aided designing of bioactive compounds with special reference to designing of carbonic anhydrase inhibitors, lipophilicity, toxicity, tadpole narcosis, bio-concentration factor, diuretic activity and carcinogenic activity of aromatic hydrocarbons and heterocycles etc. Keywords: PI index, computer-aided drug design, bioactive compound, QSAR, QSPR, QSTR, regression analysis, carbonic, anhydrace inhibitor, lipophilicity