Networking death signals to fight cancer
N. R. Gough · Science · 2015
Systems Biology Selectively killing cancer cells without inducing resistance is the holy grail of cancer therapy. Cancer cells are particularly sensitive to cell death triggered by the secreted protein TRAIL. Unfortunately, some cancer cells evade TRAIL-induced death and develop resistance by rewiring their signaling networks. So et al. used proteomic data to map a protein interaction network of the kinases that affected TRAIL-induced cell death. The modeling of information flow through the network revealed potential targets that could be exploited to develop combination therapies with TRAIL to kill cancer cells and prevent resistance. Sci. Signal. 8 , rs3 (2015).