CHRONOTHERAPY: SCIENCE AND TECHNOLOGY OF DRUG SCHEDULING ON THE BASIS OF BIOLOGICAL RHYTHM
Rajendra Awasthi, Pravin Kumar, Vivek Kumar Pawar · 2010
Drug delivery systems that precisely control the release rates or target drugs to a specific site have an enormous impact on the health care system. Over the past few years, pharmaceutical industry has focused its research in the development of various chronotherapeutic delivery systems. By choosing the optimal time to achieve the desired effect, treatment opportunities may arise, and undesirable side effects minimized. Hence the long term interest of both the public and the industry is to develop new and more effective methods on the current study focus – chronopharmaceuticals. The present article covers findings about the effects of biorhythms on various disorders, and their implications for drug therapy are discussed. Here we also reviewed the design of novel chronopharmaceutical drug delivery systems that might be able to release the therapeutic agents at predetermined intervals.