Le devenir statistique de l'ADN génomique : Modélisation des statistiques d'appariement dans différents scénarios évolutifs
Florian Massip · HAL (Le Centre pour la Communication Scientifique Directe) · 2015
In this thesis, we study the length distribution of maximal exact matches within and between eukaryotic genomes. These distributions strongly deviate from what one could expect from simple probabilistic models and, surprisingly, present a power-law behavior. To analyze these deviations, we develop mathematical frameworks taking into account complex mechanisms and that reproduce the observed deviations. We also implemented in silico sequence evolution models that reproduce these behaviors. Finally, we show that we can use our framework to assess the quality of sequences of recently sequenced genomes and to highlight the importance of unexpected biological mechanisms in eukaryotic genomes.