Rule-based modelling and simulation of drug-administration policies
Luca Bortolussi, Thilo B. Krüger, Thorsten Lehr, Verena Wolf · ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) · 2015
We investigate a model of drug administration in the con- text of a plaque-formation process responsible of Alzheimer’s disease. This is a polymerisation process, best described by a rule-based model to counteract the intrinsic combinatorial explosion of the underlying re- action network. Furthermore, there is the additional complicancy of time- dependent rates, modelling the effect of drugs. In the paper, we provide a novel and efficient rejection-based simulation algorithm that samples exactly the trajectory space and apply it to study the efficacy of different drug administration policies.