Book Received* Pharmacophore Perception, Development and Use in Drug
Osman F. Güner, Shu‐Kun Lin · 2000
Shu-Kun LinMolecular Diversity Preservation International (MDPI), Saengergasse 25, CH-4054 Basel, SwitzerlandTel.: +41 79 322 3379, Fax: +41 61 302 8918, E-mail: [email protected], URL: http://www.mdpi.org/lin/Received: 5 April 2000 / Published: 26 July 2000The book entitiled Pharmacophore Perception, Development, and Use in Drug Design, which hasbeen just released [1], is the first monograph dedicated to the topic of the pharmacophore. It isauthored by 56 experts [2] in the fields of computational chemistry and chemo- and bioinformatics.The first chapter stes the tone for the volume by giving a very interesting account of the evolution ofthe concepts of pharmacophore and related terms such as chromophore, chemotherapy (p.6), topologi-cal patterns of molecules, drug-receptor interaction (p.7), ligand-receptor binding, topographic patterns(p.8) and so on.Below is the Table of Contents:Preface. By O.F.GunerPart I: The Origins of Pharmacophore Research1. Evolution of the Pharmacophore Concept in Pharmaceutical Research. By P.GundPart II: Analog-Based Pharmacophores2. Manual Pharmacophore Generation: Visual Pattern Recognition. By O.F.Guner3. Pharmacophore Definition Using the Active Analog Approach. By D.D.Beusen,G.R.MarshallAutomated Pharmacophore Development Systems4. DISCO: What We Did Right and What We Missed. By Y.C.Martin5. HipHop: Pharmacophores Based on Multiple Common-Feature Alignments. ByO.A.Clement, A.T.Mehl6. GASP: Genetic Algorithm Superposition Program. By G.Jones, P.Willett, R.C.Glen7. Exploring Pharmacophores with Chem-X. By S.J.Cato