Abstract 1493: TAK-475, a Squalene Synthase Inhibitor, Improves Lipid Profile in Hyperlipidemic Subjects
Ed Piper, Graham Price, Yinzhong Chen · Circulation · 2006
TAK-475 decreases LDL-C by inhibiting squalene synthase; this contrasts with statins, which act on HMG-CoA reductase. Preliminary data showed that TAK-475 is safe and improves lipid profiles in ani...