Algorithm for uptake assessment in small lesions based on dynamic scintigraphy scans
Milica M. Janković, Vera Miler-Jerković, Ana Koljevic-Markovic, Dejan B. Popović · Facta universitatis - series Electronics and Energetics · 2016
The aim of our research was to develop an algorithm for estimation and visualisation of radiopharmaceutical uptake based on time-activity-curve (TAC) analysis in small regions of interest (ROI) in scintigraphic studies. The algorithm is implemented in Lab view environment (National Instruments, Texas, Austin) and comprises the following steps: 1) delineation of grid of small ROIs over the examined tissue and corresponding TAC processing; 2) background vs tissue separation; 3) the extraction of all ?suspected? ROIs where TACs are not exponentially descendent; 4) correlation analysis between a TAC corresponding to the central suspected ROI and TACs of neghboring ROIs; 5) the extraction of representative TAC for ?suspected? area by Principal Component Analysis technique; and 6) visual interpretation of radiopharmaceutical distribution in the ?suspected? area. The application of algorithm is presented in data recorded in case of histopathologically proven parathyroid tumors.