Synthesis, characterization and biological evaluation of sulfonamide based transition metal complexes
Hitesh R. Patel, Asha D. Patel · 2015
In the present study a noval 4-oxo-4-(4-sulfamoylphenylamino)but-2-enoic acid (OSPAB) was prepared by reaction of maleic anhydride with sulphanilamide. The prepared ligand was characterized by elemental analysis and spectral studies. The transition metal complexes viz. Cu 2+ , Ni 2+ , Co 2+ , Mn 2+ and Zn 2+ of OSPAB were prepared and characterized by metal-ligand (M:L) ratio, IR, reflectance spectroscopies and magnetic properties. All the prepared metal complexes and ligand were studies as antimicrobial agent. Among all the metal complexes, Zn 2+ and Cu 2+ metal complexes have shown significant activity.