The Possibilities of the Automated Morphometry in the Diagnosis of the Hyperlipoproteidemia Morphometry in the Diagnosis of the Hyperlipoproteidemias
Alexander V. Zhukotsky, N. N. Butusova, Kh M Umudov, E. M. Kogan · Biomaterials Artificial Cells and Artificial Organs · 1987
Following are the results of using the elaborated algorhythms of the structural analysis for the study of the form elements of the blood. A possibility was demonstrated to carry out a differential diagnosis of the familial hyperlipoproteidemia of the second type according to the quantitative structural parametres of the chromatin of the inter-phase nuclei of the lymphocytes of the peripheral blood. A method was developed of the automated morphometry of erythrocytes making it possible to assess the optical profile of erythrocytes according to 16 parametres. It was also registered a more vivid change of the curve of the membrane of the erythrocytes as compared with the Price-Jones spread on the same erythrocytes. With a help of a system of proposed parametres, which are 4-6-fold more informative and sensitive, than the traditional ones, it is possible to obtain the qualitatively new characteristics of the forms of erythrocytes, and not only their sizes.