The Reconstructing of Low Signal—noise Ratio Single Ion Channel Signal from Patech—clamp Recordings Sampled in the COlored Background Noise
韩晓东, LiuXiangming · 高技术通讯：英文版 · 2002
The single ion channel signal is an ionic current that can be recorded by the patch clamp technique,Hidden Markov model(HMM) algorithm has been used to convert the low signal-noise ratio(SNR) noisy recording into an idealized quantal one in the case of white background noise,The Traditional HMM algorithm is extended and adapted to the colored background noise.A new algorithm called EHMM(Extended HMM) algorithm is propsed,and mainly validated by simulation,Resultes show that it's effective.