Homology Modeling, Simulation and Docking Studies of Tau-Protein Kinase
Aluru Ranganadha Reddy, Thirupati Chinna Venkateswarulu, D. John Babu, N. Shyamala Devi · Research Journal of Pharmacy and Technology · 2014
Alzheimer's disease is a brain disorder characterized by the most common form of dementia associated with plaques and tangles in the brain. The most commonly recognized symptoms are memory loss, such as difficulty in remembering and occasional problems with remembering certain things and confusion. These symptoms are signs of a failing brain cells. The brain has 100 billion nerve cells (neurons). Each nerve cell communicates with many others to form networks. In Alzheimer's disease, increasing numbers of brain cells deteriorate as in other types of dementia. Tau-protein kinase (EC 2.7.11.26) is an enzyme that catalyzes the transferring of a phosphate group to the side chain oxygen atom of serine or threonine residues.