The total synthesis of calcium atorvastatin
Luiz Carlos Dias, Adriano S. Vieira, Eliezer J. Barreiro · Organic & Biomolecular Chemistry · 2016
A practical and convergent asymmetric route to calcium atorvastatin (1) is reported. The synthesis of calcium atorvastatin (1) was performed using the remote 1,5-anti asymmetric induction in the boron-mediated aldol reaction of β-alkoxy methylketone (4) with pyrrolic aldehyde (3) as a key step. Calcium atorvastatin was obtained from aldehyde (3) after 6 steps, with a 41% overall yield.